Nephrology
Local Ablation Dramatically Boosts Survival in Renal Cell Carcinoma
When surgery isn't an option, what's the best second choice for RCC?
Major Breakthrough: New Class of Anti-Cancer Drug Effective Against Kidney Cancer
Can a new agent block tumor growth in kidney cancer?
More than 15 Million Americans at Risk of Significant Kidney Damage
- Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide.
- H2 blockers are equally effective for acid control and pose significantly less risk.
- Long-term PPI exposure is linked to significantly increased risk of chronic kidney disease (CKD), CKD progression, and end-stage renal disease.
- The risk of developing these diseases correlated directly with the duration of therapy.
- PPI use was associated with CKD in all analyses, including a time-varying new-user design.
- Twice-daily PPI dosing was associated with a higher risk than once-daily dosing.
