Which combination provides the best outcome for high-risk NSCLC? Here's the answer.
Things are looking up for ALK-positive NSCLC patients, thanks to the recent FDA approval of Alecensa (alectinib), a highly selective ALK inhibitor that was shown to reduce the risk of disease worsening or death by 47% compared with crizotinib.
- Study found beneficial effects of early farm life on sensitization, asthma, rhinitis, and bronchial hyper-responsiveness.
- Researchers examined adults more than 10,000 adults from 14 countries.
- Children raised on farms were 54% less likely to develop asthma or hay fever and 57 percent less likely to have nasal allergies than children raised in cities.
- Children raised on farms were also 50% less likely to develop asthma than children raised in cities.
- Female children raised on farms in all of the 14 countries studied had superior lung function as adults than did women who grew up in cities.
- About 1% of all cases of chronic obstructive pulmonary disease (COPD) are attributable to alpha-1 antitrypsin deficiency.
- Approximately 15% of people who have alpha-1 antitrypsin disease have been diagnosed.
- Alpha-1 antitrypsin deficiency is inherited as an autosomal-codominant condition.
- Blood tests are available to help clinicians distinguish COPD due to alpha-1 antitrypsin deficiency from COPD due to other causes.
- Most smoking cessation guidelines advise quitting abruptly.
- This was found to be the most effective method.
- Irrespective of quitting strategy, most smokers require repeated quit attempts before they are successful.
- Primary care physicians can be secure in stressing the patients quit abruptly.
- Millions of pack years of smoking can be avoided if smokers quit cold turkey versus tapering to a quit.