Top 5 Stories from ASCO 2019

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This weekend in Chicago the American Society of Clinical Oncology hosted its 2019 Annual Meeting, featuring practice-changing research for patients with cancer. Research highlights included updates in lung and breast cancer treatment, as well as new options for predicting responses to novel therapies. MD /alert compiled a list of the top 5 research breakthroughs you may have missed.

RELAY: Combo Ramucirumab/Erlotinib Superior to Erlotinib Alone for EGFR Mutation-Positive NSCLC

Ramucirumab and erlotinib as a first-line treatment for epidermal growth factor receptor mutation-positive non-small lung cancer improved progression-free survival compared with standard-of-care treatment with erlotinib and placebo. READ MORE

Immune-Related Adverse Events Improve Overall Response Rate Following Cancer Immunotherapy

Patients with advanced cancer receiving anti-PD-1 immunotherapy who go on to have an immune-related adverse event may have better overall response rates to treatment than those patients who did not develop an immune-related adverse event. READ MORE

Ribociclib Plus Endocrine Improves Overall Survival for Premenopausal Women with Advanced Breast Cancer

Premenopausal women with hormone receptor–positive or negative advanced breast cancer who received ribociclib in combination with endocrine therapy lived nearly a year longer without disease progression than woman who received endocrine therapy alone. READ MORE

Pembrolizumab Significantly Improves 5-Year Survival for Advanced NSCLC Patients Compared With Chemotherapy

Patients with locally advanced or metastatic non-small cell lung cancer who received first-line therapy with pembrolizumab had a 5-year survival rate of 23.2%. READ MORE

Baseline TGF-β May Predict Response, PFS, OS for HCC Patients Receiving Pembrolizumab

The plasma concentration of transforming growth factor beta (TGF-β) at baseline may help predict response, progression-free survival, and overall survival in patients with hepatocellular carcinoma treated with pembrolizumab as second-line therapy. READ MORE