Omega-3 Fatty Acids and Chemotherapy: A Dangerous Combination?

By MDalert.com staff.
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The following is a brief literature review to accompany our full article on the interaction between omega-3 fatty acids and chemotherapeutic drugs in cancer patients.

  • Advise patients to abstain from fish oil supplements for at least one day before and after chemotherapy.
  • Suggest that patients also avoid eating fatty fish — mackerel, and sardines, for instance, — for at least one day before and after chemotherapy.
  • The fatty acid 16:4(n-3) has been shown to have chemotherapy-negating effects and was rapidly taken up in the plasma of human volunteers.
  • Strength of this finding: 3/5.

You can see our review article here.


  1. U.S. Food and Drug Administration. FDA Announces Qualified Health Claims for Omega-3 Fatty Acids. Accessed April 6, 2015.
  2. Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response. Houthuijzen JM, Daenen LG, Roodhart JM, et al. Nat Commun. 2014;5:5275.
  3. Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. Gelsomino G, Corsetto PA, Campia I, Montorfano G, Kopecka J, Castella B, Gazzano E, Ghigo D, Rizzo AM, Riganti C. Mol Cancer. 2013;12:137.
  4. A fishy conclusion regarding omega-3 fatty acid supplementation in cancer patients. Murphy RA, Clandinin MT, Chu QS, Arends J, Mazurak VC. Clin Nutr. 2013;32(3):466-467.
  5. Development and validation of a quantitative LC-tandem MS assay for hexadeca-4,7,10,13-tetraenoic acid in human and mouse plasma. Stigter EC, Letsiou S, vd Broek NJ, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;925:16-19.
  6. Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance. Kornfeld S, Goupille C, Vibet S, Chevalier S, Pinet A, Lebeau J, Tranquart F, Bougnoux P, Martel E, Maurin A, Richard S, Champeroux P, Mahéo K. Carcinogenesis. 2012;33(2):260-7.
  7. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. JAMA. 2012;308(10):1024-1033.
  8. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Kwak SM, Myung SK, Lee YJ, Seo HG; Korean Meta-analysis Study Group. Arch Intern Med. 2012;172(9):686-694.
  9. Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Roodhart JM, Daenen LG, Stigter EC, et al. Cancer Cell. 2011;20(3):370-383.
  10. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced non-small cell lung cancer. Murphy RA, Mourtzakis M, Chu QS, Baracos VE, Reiman T, Mazurak VC. Cancer. 2011;117(16):3774-3780.
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  13. Inhibition of proliferation by omega-3 fatty acids in chemoresistant pancreatic cancer cells. Hering J, Garrean S, Dekoj TR, Razzak A, Saied A, Trevino J, Babcock TA, Espat NJ. Ann Surg Oncol. 2007;14(12):3620-8.
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